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A new study finds that people who have had a heart attack have lower levels of brain-derived neurotrophic factor than those who never had one. The study also found that when people underwent surgery to correct damaged hearts, their symptoms could be reversed if the problem had only just emerged.

The study results are published in the October 30 issue of the Journal of the American Heart Association.

“It is good to know that the brain-derived neurotrophic factor may help brain cells grow and repair damaged tissue, and that it may help prevent and possibly reverse heart disease,” said David Zahn, M.D., lead author and an assistant professor of medicine, medicine-related sciences, and heart transplant at University of California, San Diego School of Medicine. “A significant role for this factor may help to explain how heart disease develops.”

Researchers studied data collected from 16,000 heart attack survivors from four hospitals in the United States. Participants had either had a previous heart attack or had received some type of surgery, to correct coronary blockages or remodeling, in each of their 2.1 million years since their last heart attack.

When researchers examined patients who had had a heart attack and also had been hospitalized for other heart problems before their heart attack or hospitalization, they found that for each 10-percent decline in the level of some type of neuro-trophin that normally helps brain cells recover themselves from damage, there was a corresponding decline in the function of neurons in the brain known as microglia, which make up the brain’s immune system.

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“Our study found that a person’s response to heart attacks was affected by the number of microglia that live in the brain, and in turn, their ability to produce neuro-trophin, thus helping restore the brain’s function,” Zahn said. “In fact, when an individual does not get a heart attack

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